Are you facing challenges inPROTAC drug development? We've got you covered.
We can solve issues such as the need for milder reaction conditions to tolerate more complex functional groups, the problem of longer reaction steps, the low-yield dilemma, and situations involving high impurity levels.
We are here to help you overcome the high cost of metal catalysts like Pd/Ir, the obstacles in large-scale production, racemization caused by complex conditions, and the difficulties in click chemistry for linkers using azide reagents.
We can solve problems such as the presence of more amorphous intermediates or APIs due to PEG linkers, the challenge of developing an effective recrystallization process, and issues related to poor solubility.
We've got all-round advantages spanning every stage of PROTAC drug development, from pre-clinical to commercialization, covering intermediates, drug substance (DS), and drug product (DP), all in accordance with international standards.
Our professional team is here to help you overcome complex chemical challenges with ease.
| Case | Product Type | Stage | Production Scale | Production Scale |
|---|---|---|---|---|
| A | E3 Ligase Ligand + Linker |
P3 | Tons Scale GMP Intermediates |
|
| B | DS+DP | P1/IND,P2 | Pilot Scale |
|
| C | DS | P1/IND,P2 | Pilot Scale |
|
| D | DS | P2 | Kilo Lab Scale |
|
| E | E3 Ligase Ligand + Linker |
P1 | Kilo Lab Scale |
|
| F | DS | PO | Kilo Lab Scale |
|
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